Lrat^tm1.1Bok
Targeted Allele Detail

Summary

• Symbol: Lrat^tm1.1Bok
• Name: lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase); targeted mutation 1.1, Dean Bok
• MGI ID: MGI:3777017
• Synonyms: Lrat^L-
• Gene: Lrat Location: Chr3:82799889-82811281 bp, - strand Genetic Position: Chr3, 36.81 cM
• Alliance: Lrat^tm1.1Bok page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132516
• Parent Cell Line: P1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Lrat^tm1Bok mice were crossed with a Cre transgenic mouse that removed the floxed allele in the germline. Gene inactivation was confirmed by a lack of detectable protein in immunoblot analysis of various tissues and by immunohistochemical analysis of the retina. (J:132516)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrat Mutation: 22 strains or lines available

References

• Original: J:132516 Ruiz A, et al., Somatic ablation of the Lrat gene in the mouse retinal pigment epithelium drastically reduces its retinoid storage. Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5377-87
• All: 4 reference(s)