Tg(CD34)29Dgt
Transgene Detail

Summary

• Symbol: Tg(CD34)29Dgt
• Name: transgene insertion 29, Daniel G Tenen
• MGI ID: MGI:3776897
• Transgene: Tg(CD34)29Dgt Location: unknown
• Alliance: Tg(CD34)29Dgt page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CD34)29Dgt expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CD34 (947)

  Cd34	(MGI:88329)

• Mutation details: A linearized PAC clone containing the human CD34 gene and 110 kb of promoter sequence and 26 kb of downstream sequence was used as a transgene. Two copies of the transgene inserted and expression was detected in numerous tissues with highest levels detected in the bladder, heart, lymph nodes, and lungs. Expression at the RNA and protein levels was very similar to the endogenous mouse Cd34 gene. (J:132476)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Two other founder lines (lines 8 and 14) were created with one copy of the transgene inserting for each.

References

• Original: J:132476 Radomska HS, et al., Transgenic targeting with regulatory elements of the human CD34 gene. Blood. 2002 Dec 15;100(13):4410-9
• All: 1 reference(s)