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Targeted Allele Detail
Symbol: Hprt1tm2Brd
Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 2, Allan Bradley
MGI ID: MGI:3776895
Synonyms: hprt(Myo7a)Brd, hprt(Myo7a-lacZ)Brd
Gene: Hprt1  Location: ChrX:52077014-52110536 bp, + strand  Genetic Position: ChrX, 29.31 cM, cytoband A6
Alliance: Hprt1tm2Brd page
Germline Transmission:  Earliest citation of germline transmission: J:132633
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsUsing RMCE the BAC RPCI 23-138G2 was inserted into the RMCE ready locus of Hprttm1Brd. This BAC is 219 kb in length and contains a modified Myo7a with a lacZ and frt-flanked neo cassette inserted upstream of the coding region. (J:132633)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hprt1 Mutation:  1271 strains or lines available
Original:  J:132633 Prosser HM, et al., Mosaic complementation demonstrates a regulatory role for myosin VIIa in actin dynamics of stereocilia. Mol Cell Biol. 2008 Mar;28(5):1702-12
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory