Hprt1^tm2Brd
Targeted Allele Detail

Summary

• Symbol: Hprt1^tm2Brd
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 2, Allan Bradley
• MGI ID: MGI:3776895
• Synonyms: hprt^(Myo7a)Brd, hprt^{(Myo7a-lacZ)Brd}
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^tm2Brd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132633
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Using RMCE the BAC RPCI 23-138G2 was inserted into the RMCE ready locus of Hprt^tm1Brd. This BAC is 219 kb in length and contains a modified Myo7a with a lacZ and frt-flanked neo cassette inserted upstream of the coding region. (J:132633)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1273 strains or lines available

References

• Original: J:132633 Prosser HM, et al., Mosaic complementation demonstrates a regulatory role for myosin VIIa in actin dynamics of stereocilia. Mol Cell Biol. 2008 Mar;28(5):1702-12
• All: 2 reference(s)