Cyp3a57^tm1Ahs
Targeted Allele Detail

Summary

• Symbol: Cyp3a57^tm1Ahs
• Name: cytochrome P450, family 3, subfamily a, polypeptide 57; targeted mutation 1, Alfred H Schinkel
• MGI ID: MGI:3775599
• Gene: Cyp3a57 Location: Chr5:145282089-145327736 bp, + strand Genetic Position: Chr5, 85.17 cM
• Alliance: Cyp3a57^tm1Ahs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:127366
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• The intronic sequence between exon 2 and 3 was replaced with a floxed neo cassette. (J:127366)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp3a57 Mutation: 41 strains or lines available

References

• Original: J:127366 van Herwaarden AE, et al., Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism. J Clin Invest. 2007 Nov;117(11):3583-92
• All: 1 reference(s)