Rela^tm1Asba
Targeted Allele Detail

Summary

• Symbol: Rela^tm1Asba
• Name: v-rel reticuloendotheliosis viral oncogene homolog A (avian); targeted mutation 1, Albert S Baldwin
• MGI ID: MGI:3775205
• Synonyms: p65^flox, RelA^F
• Gene: Rela Location: Chr19:5687511-5698158 bp, + strand Genetic Position: Chr19, 4.34 cM, cytoband B1-3
• Alliance: Rela^tm1Asba page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131977
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flank neo cassette with a 5' loxP site was inserted downstream of exon 8 and an additional loxP site was inserted downstream of exon 4. In vitro flp-mediated recombination was used to remove the neo cassette leaving exons 5 through 8 floxed. (J:131977)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rela Mutation: 24 strains or lines available

References

• Original: J:131977 Steinbrecher KA, et al., Loss of epithelial RelA results in deregulated intestinal proliferative/apoptotic homeostasis and susceptibility to inflammation. J Immunol. 2008 Feb 15;180(4):2588-99
• All: 14 reference(s)