Tnfrsf10b^tm1Cjk
Targeted Allele Detail

Summary

• Symbol: Tnfrsf10b^tm1Cjk
• Name: tumor necrosis factor receptor superfamily, member 10b; targeted mutation 1, Christopher J Kemp
• MGI ID: MGI:3774333
• Synonyms: Trail-r^flox
• Gene: Tnfrsf10b Location: Chr14:70004921-70021860 bp, + strand Genetic Position: Chr14, 36.1 cM
• Alliance: Tnfrsf10b^tm1Cjk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130806
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked neo cassette with a 5' loxP site was inserted upstream of exon 2 and an additional loxP site was inserted downstream of exon 2. The neo cassette was removed by flp-recombination in ES cells. (J:130806)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnfrsf10b Mutation: 29 strains or lines available

References

• Original: J:130806 Grosse-Wilde A, et al., TRAIL-R deficiency in mice enhances lymph node metastasis without affecting primary tumor development. J Clin Invest. 2008 Jan;118(1):100-10
• All: 7 reference(s)