Tg(Th-EGFP)21-31Koba
Transgene Detail

Summary

• Symbol: Tg(Th-EGFP)21-31Koba
• Name: transgene insertion 21-31, Kazuto Kobayashi
• MGI ID: MGI:3774290
• Synonyms: Tg(Th-EGFP)21-31Koba, Tg(TH-GFP)21-31, TH-GFP/21-31
• Transgene: Tg(Th-EGFP)21-31Koba Location: unknown
• Alliance: Tg(Th-EGFP)21-31Koba page

Transgene origin

• Strain of Origin: (C57BL/6J x DBA/2J)F2

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: The transgene contains 9.0 kb of upstream sequence from the rat tyrosine hydroxylase gene, the second intron of the rabbit beta-globin gene, the EGFP coding sequence and the rabbit beta-globin and SV40 polyadenylation signals. Ten copies are present per haploid genome of this line. Strong fluorescent signal is detected in typical catecholaminergic cell groups and in most dopaminergic neurons of the transgenic adult ventral midbrain. Embryonic expression begins in the dopaminergic neurons of the developing ventral midbrain around E11-E12, is dramatically reduced later in gestation, and gradually resumes postnatally. (J:131734)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:131734 Matsushita N, et al., Dynamics of tyrosine hydroxylase promoter activity during midbrain dopaminergic neuron development. J Neurochem. 2002 Jul;82(2):295-304
• All: 44 reference(s)