Eif2ak3^tm1.1Drc
Targeted Allele Detail

Summary

• Symbol: Eif2ak3^tm1.1Drc
• Name: eukaryotic translation initiation factor 2 alpha kinase 3; targeted mutation 1.1, Douglas R Cavener
• MGI ID: MGI:3774276
• Synonyms: Perk^loxP
• Gene: Eif2ak3 Location: Chr6:70821499-70882229 bp, + strand Genetic Position: Chr6, 32.09 cM
• Alliance: Eif2ak3^tm1.1Drc page

Acinar cells are lost in both Eif2ak3^tm1Drc/Eif2ak3^tm1Drc and Eif2ak3^tm1.1Drc/Eif2ak3^tm1.1Drc Tg(Ela1-cre)16Eps/0 mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76661
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Two loxP sites were introduced to intronic regions flanking the three exons encoding part of the lumenal domain, the transmembrane domain, and part of the catalytic domain. A third loxP site was introduced with a PGK-neo cassette directly downstream of the second loxP site in the same intron. (J:76661)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eif2ak3 Mutation: 51 strains or lines available

References

• Original: J:76661 Zhang P, et al., The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Mol Cell Biol. 2002 Jun;22(11):3864-74
• All: 29 reference(s)