Eomes^tm1Whk
Targeted Allele Detail

Summary

• Symbol: Eomes^tm1Whk
• Name: eomesodermin; targeted mutation 1, William H Klein
• MGI ID: MGI:3774146
• Synonyms: Eomes^flox, Tbr2^flox
• Gene: Eomes Location: Chr9:118307259-118315176 bp, + strand Genetic Position: Chr9, 70.21 cM, cytoband F3
• Alliance: Eomes^tm1Whk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130570
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A neo cassette flanked by frt sites with a 3' loxP site was inserted into intron 3 and an additional loxP site was inserted into intron 2 resulting in a floxed exon 3. The neo cassette was removed by germ-line, flp-mediated recombination. (J:130570)

Expression

In Mice Carrying this Mutation:

19 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eomes Mutation: 41 strains or lines available

References

• Original: J:130570 Mao CA, et al., Eomesodermin, a target gene of Pou4f2, is required for retinal ganglion cell and optic nerve development in the mouse. Development. 2008 Jan;135(2):271-80
• All: 12 reference(s)