Sulf1^Gt(XM190)Byg
Gene trapped Allele Detail

Summary

• Symbol: Sulf1^Gt(XM190)Byg
• Name: sulfatase 1; gene trap XM190, BayGenomics
• MGI ID: MGI:3774126
• Synonyms: Sulf1^{Gt(XM190)Avor}
• Gene: Sulf1 Location: Chr1:12762501-12931416 bp, + strand Genetic Position: Chr1, 3.35 cM
• Alliance: Sulf1^Gt(XM190)Byg page

Mutation origin

• Mutant Cell Line: XM190
• Germline Transmission: Earliest citation of germline transmission: J:130163
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0Lxf Vector Type: gene trap
• Mutation details: The gene trap vector pGT0Lxf was inserted between exon 1B and exon 2. Expression of the lacZ gene was confirmed by beta-galactosidase assay. Expression from the allele is reduces compared to in wild-type mice. (J:130163)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XM190	CC325289 ; (MGI Seq Detail)	5' RACE	Chr1:12762693-12762904 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  78 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	20 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sulf1 Mutation: 110 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:130163 Ratzka A, et al., Redundant function of the heparan sulfate 6-O-endosulfatases Sulf1 and Sulf2 during skeletal development. Dev Dyn. 2008 Feb;237(2):339-53
• All: 2 reference(s)