Tg(IGH@,IGL@)1Skmr
Transgene Detail

Summary

• Symbol: Tg(IGH@,IGL@)1Skmr
• Name: transgene insertion 1, Sanjeev Kumar
• MGI ID: MGI:3772691
• Transgene: Tg(IGH@,IGL@)1Skmr Location: unknown
• Alliance: Tg(IGH@,IGL@)1Skmr page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1 x C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(IGH@,IGL@)1Skmr expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  human	IGH (3492)
  human	IGL (3535)

• Mutation details: A transgenic construct containing the human immunoglobulin heavy gene and a second transgenic construct containing the human immunoglobulin light gene were co-injected into fertilized oocytes. These transgenic mice express and secrete a complete functional human IgG, immunoglobulin and are naturally tolerant to human IgG. Progeny mice with the highest titers of assembled human IgG were chosen for further breeding and maintenance of the strain on the C57BL/6 background. (J:131009)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:131009 Kumar S, Expression of a human IgG in transgenic mice. MGI Direct Data Submission. 2008
• All: 1 reference(s)