Bcat2^tm1.1Clyn
Targeted Allele Detail

Summary

• Symbol: Bcat2^tm1.1Clyn
• Name: branched chain aminotransferase 2, mitochondrial; targeted mutation 1.1, Christopher Lynch
• MGI ID: MGI:3772356
• Gene: Bcat2 Location: Chr7:45219773-45239134 bp, + strand Genetic Position: Chr7, 29.36 cM
• Alliance: Bcat2^tm1.1Clyn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:129967
• Parent Cell Line: XSV1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette and loxP site were introduced into intron 3 and intron 6, respectively, via homologous recombination. In vivo cre-mediated recombination removed the neo cassette, leaving exons 4 - 6 flanked by loxP sites. (J:129967)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcat2 Mutation: 198 strains or lines available

References

• Original: J:129967 She P, et al., Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle. Cell Metab. 2007 Sep;6(3):181-94
• All: 2 reference(s)