Cfp^tm1.1Song
Targeted Allele Detail

Summary

• Symbol: Cfp^tm1.1Song
• Name: complement factor properdin; targeted mutation 1.1, Wen-Chao Song
• MGI ID: MGI:3771611
• Synonyms: fP^flox, properdin rescued knockout
• Gene: Cfp Location: ChrX:20791693-20797794 bp, - strand Genetic Position: ChrX, 16.44 cM, cytoband A3
• Alliance: Cfp^tm1.1Song page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130108
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was constructed where a loxP site was inserted upstream of exon 3, and a FRT flanked neomycin resistance cassette followed by a loxP site was inserted downstream of exon 5. Upon recombination, the neomycin cassette inserted in the intended location but the upstream loxP site failed to recombine. FLPe recombination removed the FRT-flanked neomycin cassette located in intron 5 and endogenous gene expression was restored. (J:130108)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cfp Mutation: 3 strains or lines available

References

• Original: J:130108 Kimura Y, et al., Activator-specific requirement of properdin in the initiation and amplification of the alternative pathway complement. Blood. 2008 Jan 15;111(2):732-40
• All: 2 reference(s)