Pyy^tm1.1Batt
Targeted Allele Detail

Summary

• Symbol: Pyy^tm1.1Batt
• Name: peptide YY; targeted mutation 1.1, Rachel L Batterham
• MGI ID: MGI:3771165
• Synonyms: PyyKO
• Gene: Pyy Location: Chr11:101997502-101998658 bp, - strand Genetic Position: Chr11, 65.48 cM
• Alliance: Pyy^tm1.1Batt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:129742
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: An frt-flank neo cassette with a 3' lox P site was inserted upstream of the open reading frame and an additional lox P site was inserted downstream of the open reading frame. Flp-mediated recombination was used to remove the neo cassette and germ line cre-mediated recombination was used to remove the open reading frame. The absence of protein product was confirmed by the absence of protein product in the plasma. (J:129742)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pyy Mutation: 9 strains or lines available

References

• Original: J:129742 Batterham RL, et al., Critical role for peptide YY in protein-mediated satiation and body-weight regulation. Cell Metab. 2006 Sep;4(3):223-33
• All: 6 reference(s)