Tg(REN)8-12Afu
Transgene Detail

Summary

• Symbol: Tg(REN)8-12Afu
• Name: transgene insertion 8-12, Akiyoshi Fukamizu
• MGI ID: MGI:3769590
• Synonyms: hRN8-12, RN, TgN(hRN)
• Transgene: Tg(REN)8-12Afu Location: unknown Genetic Position: Chr6, Syntenic
• Alliance: Tg(REN)8-12Afu page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(REN)8-12Afu expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  REN (5972)

  Ren1	(MGI:97898)
  Ren2	(MGI:97899)

• Mutation details: A 15-kB genomic fragment containing the entire human renin gene and including 3Kb of 5' flanking region and 3'flanking region was used to create transgenic mice. Copy number is estimated to be 2 or more. High levels of mRNA encoding human renin are found in transgenic mouse kidney, and significant levels are detected in brain, lung, thymus, testis and spleen. Low levels are detectable in heart, pancreas and stomach. In addition to line 8-12, lines 8-3 and 8-5 were also created, but these lines express at lower levels than line 8-12. (J:129503)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:129503 Fukamizu A, et al., Tissue-specific expression of the human renin gene in transgenic mice. Biochem Biophys Res Commun. 1989 Dec 15;165(2):826-32
• All: 40 reference(s)