Ncoa6^tm2Jxu
Targeted Allele Detail

Summary

• Symbol: Ncoa6^tm2Jxu
• Name: nuclear receptor coactivator 6; targeted mutation 2, Jianming Xu
• MGI ID: MGI:3769253
• Synonyms: NCoA6^L2m
• Gene: Ncoa6 Location: Chr2:155232585-155315741 bp, - strand Genetic Position: Chr2, 77.26 cM, cytoband H2
• Alliance: Ncoa6^tm2Jxu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:129067
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: Nucleotide substitution was used to convert the LSQLL motif in exon 9 encoded by TTAAGCCAACTTCTT to GCAAGCCAAGCTCTT to change the motif to ASQAL. This modification results in an abrogation of protein protein interactions with Nr1h3 and Esr1. A floxed neo cassette was inserted upstream of exon 9 and subsequently removed by cre-mediated recombination. The expression of the modified protein was confirmed by western blot analysis on liver extracts. (J:129067)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ncoa6 Mutation: 100 strains or lines available

References

• Original: J:129067 Li Q, et al., Tissue- and nuclear receptor-specific function of the C-terminal LXXLL motif of coactivator NCoA6/AIB3 in mice. Mol Cell Biol. 2007 Dec;27(23):8073-86
• All: 1 reference(s)