Gt(ROSA)26Sor^{tm1(EWSR1/FLI1)Sbk}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(EWSR1/FLI1)Sbk}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Suzanne J Baker
• MGI ID: MGI:3769110
• Synonyms: E/F, Rosa26^{loxP-STOP-loxP-HA-EWSR1/FLI1}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(EWSR1/FLI1)Sbk} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:129039
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(EWSR1/FLI1)Sbk} expresses 2 genes
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  EWSR1 (2130)

  Ewsr1

  (MGI:99960)

  human

  FLI1 (2313)

  Fli1	(MGI:95554)

• Mutation details: A floxed neo cassette with a STOP codon and 4 poly(A) sequences, and a hemagglutinin-tagged fusion of EWSR1 and FLI1 was introduced into the locus. (J:129039)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 942 strains or lines available

References

• Original: J:129039 Torchia EC, et al., EWS/FLI-1 induces rapid onset of myeloid/erythroid leukemia in mice. Mol Cell Biol. 2007 Nov;27(22):7918-34
• All: 1 reference(s)