Tgfbr1tm1Mulm
Targeted Allele Detail
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Symbol: |
Tgfbr1tm1Mulm |
Name: |
transforming growth factor, beta receptor I; targeted mutation 1, Christine L Mummery |
MGI ID: |
MGI:3767608 |
Synonyms: |
ALK5KI |
Gene: |
Tgfbr1 Location: Chr4:47353222-47414926 bp, + strand Genetic Position: Chr4, 26.02 cM
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Alliance: |
Tgfbr1tm1Mulm page
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Germline Transmission: |
Earliest citation of germline transmission:
J:128498
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted |
Mutation: |
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Single point mutation
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Mutation details: The coding region was replaced with one containing a A to C substitution in exon 4 resulting in the substitution of alanine for aspartic acid at position 266 (D266A). This mutation prevents SMAD2 and SMAD3 activation but does not affect interacts with Acvrl1. RT-PCR analysis on spleen and liver was used to confirm the expression of the modified transcript.
(J:128498)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Tgfbr1 Mutation: |
36 strains or lines available
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Original: |
J:128498 Carvalho RL, et al., Compensatory signalling induced in the yolk sac vasculature by deletion of TGF receptors in mice. J Cell Sci. 2007 Dec 15;120(Pt 24):4269-77 |
All: |
2 reference(s) |
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