Stim1^Sax
Chemically induced Allele Detail

Summary

• Symbol: Stim1^Sax
• Name: stromal interaction molecule 1; Saxcoburggotski
• MGI ID: MGI:3764828
• Gene: Stim1 Location: Chr7:101917013-102086526 bp, + strand Genetic Position: Chr7, 54.71 cM
• Alliance: Stim1^Sax page

Severe hemorrhage in Stim1^Sax/Stim1^Sax mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: Treatment with ENU was used to induce an A to G transition at nucleotide 444 of exon 2 resulting in an amino acid exchange of glycine for aspartic acid at position 84 (D84G). (J:127381)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stim1 Mutation: 46 strains or lines available

References

• Original: J:127381 Grosse J, et al., An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice. J Clin Invest. 2007 Nov;117(11):3540-50
• All: 1 reference(s)