Cxcl14^tm1Tha
Targeted Allele Detail

Summary

• Symbol: Cxcl14^tm1Tha
• Name: C-X-C motif chemokine ligand 14; targeted mutation 1, Takahiko Hara
• MGI ID: MGI:3763373
• Synonyms: CXCL14^-
• Gene: Cxcl14 Location: Chr13:56436456-56444364 bp, - strand Genetic Position: Chr13, 30.06 cM
• Alliance: Cxcl14^tm1Tha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126841
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A Neo cassette replaced sequence containing the translation initiation site and entire exon 2 of the gene. Northern and Western blot analyses confirmed transcripts and protein was absent. (J:126841)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cxcl14 Mutation: 15 strains or lines available

References

• Original: J:126841 Nara N, et al., Disruption of CXC motif chemokine ligand-14 in mice ameliorates obesity-induced insulin resistance. J Biol Chem. 2007 Oct 19;282(42):30794-803
• All: 3 reference(s)