Tg(Myh6-MT2A)15Pne
Transgene Detail

Summary

• Symbol: Tg(Myh6-MT2A)15Pne
• Name: transgene insertion 15, Paul N Epstein
• MGI ID: MGI:3763353
• Synonyms: MT, MT-TG, My-MT-IIa
• Transgene: Tg(Myh6-MT2A)15Pne Location: unknown
• Alliance: Tg(Myh6-MT2A)15Pne page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-MT2A)15Pne expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MT2A (4502)

  Mt2	(MGI:97172)

• Mutation details: This transgene contains human MT2A under the control of the Myh6 promoter along with the first 2 introns and the first three non-coding exons. Expression is cardiac-specific. (J:100354)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

4 lines containing this transgene were created (12, 15, 07 and 01) with over-expression 10- or 130-fold higher than baseline. Identical phenotypes were observed in mice over-expressing 10-fold (line 15) or 130-fold (line 01) higher than baseline. Line 15 was chosen as the representative line.

References

• Original: J:100354 Kang YJ, et al., Overexpression of metallothionein in the heart of transgenic mice suppresses doxorubicin cardiotoxicity. J Clin Invest. 1997 Sep 15;100(6):1501-6
• All: 11 reference(s)