Tacc3^tm1Tno
Targeted Allele Detail

Summary

• Symbol: Tacc3^tm1Tno
• Name: transforming, acidic coiled-coil containing protein 3; targeted mutation 1, Tetsuo Noda
• MGI ID: MGI:3763218
• Synonyms: Tacc3^CN
• Gene: Tacc3 Location: Chr5:33815472-33836339 bp, + strand Genetic Position: Chr5, 17.83 cM
• Alliance: Tacc3^tm1Tno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126471
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was introduced into intron 5 and an additional loxP site was inserted into intron 4. Western blot analysis on prottein lysates extracted from whole E9.5 embryos revealed that protein expression to be only 5% of wild-type. (J:126471)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tacc3 Mutation: 28 strains or lines available

References

• Original: J:126471 Yao R, et al., TACC3 is required for the proper mitosis of sclerotome mesenchymal cells during formation of the axial skeleton. Cancer Sci. 2007 Apr;98(4):555-62
• All: 1 reference(s)