Erc1^tm1Sud
Targeted Allele Detail

Summary

• Symbol: Erc1^tm1Sud
• Name: ELKS/RAB6-interacting/CAST family member 1; targeted mutation 1, Thomas C Sudhof
• MGI ID: MGI:3763189
• Synonyms: E1X, ELKS1 KO, ELKS1^nc-KO
• Gene: Erc1 Location: Chr6:119547757-119825128 bp, - strand Genetic Position: Chr6, 56.86 cM, cytoband F1
• Alliance: Erc1^tm1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:134026
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A targeting vector was designed to flank exon 3 of the gene with loxP sites and insert a FRT-flanked neomycin resistance cassette in intron 3 (within the loxP sites). Resultant carrier mice were crossed with a germline Cre transgenic strain driven by a protamine 1 (Prm1) promoter on a mixed C57BL/6 and 129 background to remove both exon 3 and the neomycin cassette. (J:134026, J:216293)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Erc1 Mutation: 61 strains or lines available

References

• Original: J:134026 Sudhof TC, Generation of an Erc1 knock-out mouse. MGI Direct Data Submission. 2008
• All: 2 reference(s)