Siah1b^tm1Ddlb
Targeted Allele Detail

Summary

• Symbol: Siah1b^tm1Ddlb
• Name: siah E3 ubiquitin protein ligase 1B; targeted mutation 1, Daivd D L Bowtell
• MGI ID: MGI:3761096
• Synonyms: Siah1b^-
• Gene: Siah1b Location: ChrX:162853701-162859489 bp, - strand Genetic Position: ChrX, 76.11 cM
• Alliance: Siah1b^tm1Ddlb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126183
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 was replaced with a neo cassette. Western blot analysis of protein extracts from mouse embryonic fibroblast cells confirmed the expression of protein was reduced by half the level observed in wild-type cells. (J:126183)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Siah1b Mutation: 15 strains or lines available

References

• Original: J:126183 Frew IJ, et al., Normal p53 function in primary cells deficient for Siah genes. Mol Cell Biol. 2002 Dec;22(23):8155-64
• All: 1 reference(s)