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Targeted Allele Detail
Symbol: Ankrd2tm1Krc
Name: ankyrin repeat domain 2 (stretch responsive muscle); targeted mutation 1, Kenneth R Chien
MGI ID: MGI:3760784
Gene: Ankrd2  Location: Chr19:42024439-42033549 bp, + strand  Genetic Position: Chr19, 35.65 cM, cytoband D1
Alliance: Ankrd2tm1Krc page
Germline Transmission:  Earliest citation of germline transmission: J:125819
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe first 2 exons and half of exon 3 were replaced by cDNA encoding lacZ and a pGK neo cassette, bringing the beta-galactosidase cDNA under the control of the endogenous promoter while ablating the endogenous gene. Northern and Western blot analysis on skeletal muscle confirmed absence of Ankrd2 RNA and protein, respectively. (J:125819, J:214867)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ankrd2 Mutation:  10 strains or lines available
Original:  J:125819 Barash IA, et al., Structural and regulatory roles of muscle ankyrin repeat protein family in skeletal muscle. Am J Physiol Cell Physiol. 2007 Jul;293(1):C218-27
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
The Jackson Laboratory