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Targeted Allele Detail
Symbol: Ankrd1tm1Krc
Name: ankyrin repeat domain 1 (cardiac muscle); targeted mutation 1, Kenneth R Chien
MGI ID: MGI:3760783
Gene: Ankrd1  Location: Chr19:36089365-36097244 bp, - strand  Genetic Position: Chr19, 30.52 cM, cytoband C3
Alliance: Ankrd1tm1Krc page
Germline Transmission:  Earliest citation of germline transmission: J:125819
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe first 2 exons were replaced by cDNA encoding lacZ and a pGK neo cassette, bringing the beta-galactosidase cDNA under the control of the endogenous promoter while ablating the endogenous gene. Northern and Western blot analysis on heart confirmed absence of Ankrd2 RNA and protein, respectively. (J:125819, J:215212)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ankrd1 Mutation:  17 strains or lines available
Original:  J:125819 Barash IA, et al., Structural and regulatory roles of muscle ankyrin repeat protein family in skeletal muscle. Am J Physiol Cell Physiol. 2007 Jul;293(1):C218-27
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
The Jackson Laboratory