Derl3^Gt(IZ)1Zsj
Gene trapped Allele Detail

Summary

• Symbol: Derl3^Gt(IZ)1Zsj
• Name: Der1-like domain family, member 3; gene trap 1, Zai-Si Ji
• MGI ID: MGI:3759585
• Synonyms: IZP6
• Gene: Derl3 Location: Chr10:75729247-75731775 bp, + strand Genetic Position: Chr10, 38.61 cM, cytoband B5.3
• Alliance: Derl3^Gt(IZ)1Zsj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74141
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: Vector integration together with a 25bp deletion occurred 0.2 Kb upstream of the first exon. The vector contains an IRES-lacZ upstrteam of a Ppg kinase- neomycin cassette. (J:74141)

Expression

In Mice Carrying this Mutation:

30 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Derl3 Mutation: 10 strains or lines available

Notes

LacZ is strongly expressed in the spleen, lung, and liver of heterozygous adults. Weak expression is seen in the brain and kidney with very little expression in the heart and skeletal muscle.

References

• Original: J:74141 Tsukahara M, et al., A novel putative transmembrane protein, IZP6, is expressed in neural cells during embryogenesis. Dev Growth Differ. 2001 Jun;43(3):285-93
• All: 1 reference(s)