Clca1^tm1.1Lex
Targeted Allele Detail

Summary

• Symbol: Clca1^tm1.1Lex
• Name: chloride channel accessory 1; targeted mutation 1.1, Lexicon Genetics
• MGI ID: MGI:3759581
• Synonyms: Gob-5^-, GOB5-KO allele, GOB5-KO deletion allele
• Gene: Clca1 Location: Chr3:144710298-144738537 bp, - strand Genetic Position: Chr3, 69.26 cM
• Alliance: Clca1^tm1.1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125158
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 7 was removed by cre-mediated recombination using a protamine-cre (line unspecified; background given as 129/SvEvBrd). Removal of the exon was confirmed by PCR. (J:125158)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Clca1 Mutation: 57 strains or lines available

References

• Original: J:125158 Long AJ, et al., Gob-5 contributes to goblet cell hyperplasia and modulates pulmonary tissue inflammation. Am J Respir Cell Mol Biol. 2006 Sep;35(3):357-65
• All: 1 reference(s)