Tg(Prnp-SNCA*)1Mgsp
Transgene Detail

Summary

• Symbol: Tg(Prnp-SNCA*)1Mgsp
• Name: transgene insertion 1, Maria Grazia Spillantini
• MGI ID: MGI:3758656
• Transgene: Tg(Prnp-SNCA*)1Mgsp Location: unknown
• Alliance: Tg(Prnp-SNCA*)1Mgsp page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-SNCA*)1Mgsp expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

• Mutation details: The construct consisted of the sequence expressing human alpha-synuclein 1-120 which is truncated, lacking the final 20 amino acids inserted downstream of the mouse prion protein promoter. These mice were crossed to C57BL/6JOlaHsd mice which lack alpha-synuclein as a result of a spontaneous deletion of the alpha-SNCA locus. Transgenic expression of the truncated protein is more widespread in the substantia nigra and striatum than that observed in mice with the same transgene expressed by the tyrosine hydroxylase promoter. (J:108310, J:125212)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:125212 Michell AW, et al., The effect of truncated human alpha-synuclein (1-120) on dopaminergic cells in a transgenic mouse model of Parkinson's disease. Cell Transplant. 2007;16(5):461-74
• All: 2 reference(s)