Ophn1tm1Bill
Targeted Allele Detail
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Symbol: |
Ophn1tm1Bill |
Name: |
oligophrenin 1; targeted mutation 1, Pierre Billuart |
MGI ID: |
MGI:3757609 |
Gene: |
Ophn1 Location: ChrX:97597883-97934631 bp, - strand Genetic Position: ChrX, 42.94 cM, cytoband C2
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Alliance: |
Ophn1tm1Bill page
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Germline Transmission: |
Earliest citation of germline transmission:
J:124943
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129S2/SvPas
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A loxP flanked hygromycin resistance cassette was inserted into exon 9 of this X chromosome gene. Chimeric male mice were mated with Cre-recombinase transgenic female mice to remove the selection cassette. The remaining loxP site caused a frameshift mutation and a premature STOP codon. Hemizygous males expressed no protein as determined by Western blots on brain and liver extracts.
(J:124943)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ophn1 Mutation: |
10 strains or lines available
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Original: |
J:124943 Khelfaoui M, et al., Loss of X-linked mental retardation gene oligophrenin1 in mice impairs spatial memory and leads to ventricular enlargement and dendritic spine immaturity. J Neurosci. 2007 Aug 29;27(35):9439-50 |
All: |
13 reference(s) |
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