Timd2^{tm1(GAL4)Pdre}
Targeted Allele Detail

Summary

• Symbol: Timd2^{tm1(GAL4)Pdre}
• Name: T cell immunoglobulin and mucin domain containing 2; targeted mutation 1, Paul D Rennert
• MGI ID: MGI:3723608
• Gene: Timd2 Location: Chr11:46559787-46597888 bp, - strand Genetic Position: Chr11, 28.05 cM
• Alliance: Timd2^{tm1(GAL4)Pdre} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:125054
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The exons encoding the signal peptide and Ig domains were replaced with a GAL4 and neo cassette. Correct insertion was confirmed by Southern blot. Absence of mRNA expression was confirmed in all tissues examined including spleen, lymph node, thymus and kidney. (J:125054)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Timd2 Mutation: 21 strains or lines available

References

• Original: J:125054 Rennert PD, et al., T cell, Ig domain, mucin domain-2 gene-deficient mice reveal a novel mechanism for the regulation of Th2 immune responses and airway inflammation. J Immunol. 2006 Oct 1;177(7):4311-21
• All: 1 reference(s)