Pik3cg^tm2Ehi
Targeted Allele Detail

Summary

• Symbol: Pik3cg^tm2Ehi
• Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; targeted mutation 2, Emilio Hirsch
• MGI ID: MGI:3722941
• Synonyms: p110gammaCAAX, Pikgamma^CX
• Gene: Pik3cg Location: Chr12:32223472-32258658 bp, - strand Genetic Position: Chr12, 13.74 cM, cytoband B
• Alliance: Pik3cg^tm2Ehi page

Spontaneous skin lesions in Pik3cg^tm2Ehi/Pik3cg^tm2Ehi mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124856
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The locus encoding the catalytic subunit was replaced with a chimeric minigene containing a mutant form of the human cDNA in which the CAAX motif was added at its 5' end. (J:124856)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pik3cg Mutation: 59 strains or lines available

References

• Original: J:124856 Costa C, et al., Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase {gamma}. Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14354-9
• All: 2 reference(s)