Tg(CAG-EGFP/TSC22D1)1Kawa
Transgene Detail

Summary

• Symbol: Tg(CAG-EGFP/TSC22D1)1Kawa
• Name: transgene insertion 1, Hitoshi Kawamata
• MGI ID: MGI:3722170
• Synonyms: Tg(ACTB-EGFP/TSC22D1)1Kawa, Tg(CAG-TGFB1i4/EGFP), TSC-22 transgene
• Transgene: Tg(CAG-EGFP/TSC22D1)1Kawa Location: unknown
• Alliance: Tg(CAG-EGFP/TSC22D1)1Kawa page

Transgene origin

• Strain of Origin: C57BL/6 and DBA/2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(CAG-EGFP/TSC22D1)1Kawa expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TSC22D1 (8848)

  Tsc22d1

  (MGI:109127)

• Mutation details: This transgene contains the chicken beta-actin promoter and the cytomegalovirus immediate-early (CMV-IE) enhancer driving expression of a fusion gene consisting of the enhanced green fluorescent protein coding sequence joined to the full-length open reading frame of the human TSC22 domain family, member 1 gene. A human salivary gland tumor cell line stably transfected with the same construct minus the beta-actin promoter exhibits fluorescence in the cytoplasm, but not in the nucleus; when cells of this line are induced to undergo apoptosis by treatment with 5-fluorouracil, the fluorescent fusion protein is translocated to the nucleus. (J:104881, J:124640, J:124641)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:104881 The RIKEN BioResource Center, Information obtained from The RIKEN BioResource Center. Unpublished. 2006-2013
• All: 3 reference(s)