Agtr1a^tm1Ecl
Targeted Allele Detail

Summary

• Symbol: Agtr1a^tm1Ecl
• Name: angiotensin II receptor, type 1a; targeted mutation 1, Eric Clauser
• MGI ID: MGI:3721911
• Synonyms: AT1aMUT, AT1aN11S/delta329
• Gene: Agtr1a Location: Chr13:30520424-30566850 bp, + strand Genetic Position: Chr13, 13.19 cM
• Alliance: Agtr1a^tm1Ecl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:124206
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: A point mutation was introduced into exon 3 causing an asparagine to serine substitution at amino acid 111 (N111S). A C-terminal deletion of the coding region was also introduced at position 329. A hygro cassette flanked by loxP sites was introduced into 3' UTR of exon 3. Homozygous mice had normal expression of the gene as determined by quantitative RT PCR of several tissues. (J:124206)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Agtr1a Mutation: 40 strains or lines available

References

• Original: J:124206 Billet S, et al., Gain-of-function mutant of angiotensin II receptor, type 1A, causes hypertension and cardiovascular fibrosis in mice. J Clin Invest. 2007 Jul;117(7):1914-25
• All: 2 reference(s)