Tg(APOE-DGAT2)24Far
Transgene Detail

Summary

• Symbol: Tg(APOE-DGAT2)24Far
• Name: transgene insertion 24, Bob Farese
• MGI ID: MGI:3720356
• Synonyms: Liv-DGAT2-low, LivLe6-DGAT2 (low)
• Transgene: Tg(APOE-DGAT2)24Far Location: unknown
• Alliance: Tg(APOE-DGAT2)24Far page

Transgene origin

• Strain of Origin: C57BL/6NHsd

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(APOE-DGAT2)24Far expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  DGAT2 (84649)

  Dgat2

  (MGI:1915050)

• Mutation details: The LivLE6-DGAT2 transgene was designed with promoter and enhancer sequences of the human apolipoprotein E gene placed upstream of a 1.2 kb human acyl-CoA:diacylglycerol acyltransferase 2 (DGAT2) cDNA sequence. This transgene was microinjected into C57BL/6NHsd fertilized eggs, and the resulting transgenic offspring were bred to C57BL/6NHsd. Mice from founder line 24 (referred to as Liv-DGAT2-low) have an approximately 2-fold increase in total hepatic DGAT2 mRNA/protein expression, with no reported overexpression in kidney, brain, or skeletal muscle. (J:124005)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:124005 Monetti M, et al., Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab. 2007 Jul;6(1):69-78
• All: 2 reference(s)