Mtm1^tm1.2Jman
Targeted Allele Detail

Summary

• Symbol: Mtm1^tm1.2Jman
• Name: X-linked myotubular myopathy gene 1; targeted mutation 1.2, Jean-Louis Mandel
• MGI ID: MGI:3720064
• Synonyms: MTM1L2
• Gene: Mtm1 Location: ChrX:70254373-70359019 bp, + strand Genetic Position: ChrX, 36.55 cM
• Alliance: Mtm1^tm1.2Jman page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81791
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129T1/Sv-Dnd1^Ter

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: This allele is created from Mtm1^tm1Jman ES cell by transfection of the Cre recombinase. Cre-mediated recombination results in deletion of the neo cassette only and leaving exon 4 contained within flanking loxP sites. (J:81791)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mtm1 Mutation: 27 strains or lines available

References

• Original: J:81791 Buj-Bello A, et al., The lipid phosphatase myotubularin is essential for skeletal muscle maintenance but not for myogenesis in mice. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15060-5
• All: 3 reference(s)