Gata3^tm1Mbu
Targeted Allele Detail

Summary

• Symbol: Gata3^tm1Mbu
• Name: GATA binding protein 3; targeted mutation 1, Meinrad Busslinger
• MGI ID: MGI:3719567
• Synonyms: Gata3^ex4GFP, Gata3^tm1Bchd
• Gene: Gata3 Location: Chr2:9861889-9894845 bp, - strand Genetic Position: Chr2, 6.69 cM
• Alliance: Gata3^tm1Mbu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104408
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert loxP sites flanking exon 4. Downstream of the floxed exon, an frt-flanked sequence containing a stop cassette-IRES-GFP-neo was inserted into the locus. (J:104408)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gata3 Mutation: 31 strains or lines available

References

• Original: J:104408 Grote D, et al., Pax2/8-regulated Gata3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney. Development. 2006 Jan;133(1):53-61
• All: 2 reference(s)