Mdc1Tn(pb-ZG-s)1.1Mrc
Transposon induced Allele Detail
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Symbol: |
Mdc1Tn(pb-ZG-s)1.1Mrc |
Name: |
mediator of DNA damage checkpoint 1; transposon insertion 1.1, Mario R Capecchi |
MGI ID: |
MGI:3719413 |
Gene: |
Mdc1 Location: Chr17:36152407-36170562 bp, + strand Genetic Position: Chr17, 18.7 cM
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Alliance: |
Mdc1Tn(pb-ZG-s)1.1Mrc page
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Strain of Origin: |
Not Applicable
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Allele Type: |
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Transposon induced |
Mutation: |
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Transposon insertion
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Mutation details: piggyBac transposase mediated recombination inserted the ZG-s transposable gene-trap vector into this gene. The gene-trap vector consists of piggyBac terminal repeats and internal sequence with all potential splice donor sites removed flanking a loxP site, a splice acceptor site, an IRES-beta-galactosidase-polyA cassette, an FRT site, a CAG-eGFP-polyA cassette, a loxP site, a lox5171 site, and an FRT site. Flp-mediated recombination removes the eGFP cassette. Cre-mediated recombination removes the splice acceptor and beta-galactosidase cassette restoring gene expression.
(J:123007)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Mdc1 Mutation: |
73 strains or lines available
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Original: |
J:123007 Wu S, et al., Toward simpler and faster genome-wide mutagenesis in mice. Nat Genet. 2007 Jul;39(7):922-30 |
All: |
1 reference(s) |
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