Runx2^{Tn(pb-ZG-s)1.1Mrc}
Transposon induced Allele Detail

Summary

• Symbol: Runx2^{Tn(pb-ZG-s)1.1Mrc}
• Name: runt related transcription factor 2; transposon insertion 1.1, Mario R Capecchi
• MGI ID: MGI:3719411
• Gene: Runx2 Location: Chr17:44806873-45125518 bp, - strand Genetic Position: Chr17, 21.33 cM
• Alliance: Runx2^{Tn(pb-ZG-s)1.1Mrc} page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Transposon induced (Reporter)
• Mutation: Transposon insertion
• Mutation details: piggyBac transposase mediated recombination inserted the ZG-s transposable gene-trap vector into this gene. The gene-trap vector consists of piggyBac terminal repeats and internal sequence with all potential splice donor sites removed flanking a loxP site, a splice acceptor site, an IRES-beta-galactosidase-polyA cassette, an FRT site, a CAG-eGFP-polyA cassette, a loxP site, a lox5171 site, and an FRT site. Flp-mediated recombination removes the eGFP cassette. Cre-mediated recombination removes the splice acceptor and beta-galactosidase cassette restoring gene expression. (J:123007)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Runx2 Mutation: 45 strains or lines available

References

• Original: J:123007 Wu S, et al., Toward simpler and faster genome-wide mutagenesis in mice. Nat Genet. 2007 Jul;39(7):922-30
• All: 1 reference(s)