Il31ra^tm1Ngh
Targeted Allele Detail

Summary

• Symbol: Il31ra^tm1Ngh
• Name: interleukin 31 receptor A; targeted mutation 1, Nico Ghilardi
• MGI ID: MGI:3717594
• Synonyms: Il-13ralpha
• Gene: Il31ra Location: Chr13:112649439-112717266 bp, - strand Genetic Position: Chr13, 63.75 cM
• Alliance: Il31ra^tm1Ngh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123198
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 5-8, which encode the ligand-binding cytokine receptor homology domain, were replaced with a neomycin resistance cassette. Absence of expression was confirmed by quantitative Taqman PCR. (J:123198)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il31ra Mutation: 82 strains or lines available

References

• Original: J:123198 Perrigoue JG, et al., IL-31-IL-31R interactions negatively regulate type 2 inflammation in the lung. J Exp Med. 2007 Mar 19;204(3):481-7
• All: 4 reference(s)