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Tg(ACTB-tTS)1Mllo
Transgene Detail
Summary
Symbol: Tg(ACTB-tTS)1Mllo
Name: transgene insertion 1, Moises Mallo
MGI ID: MGI:3717162
Synonyms: beta-actin-tTS, beta-act-tTS
Transgene: Tg(ACTB-tTS)1Mllo  Location: unknown  
Alliance: Tg(ACTB-tTS)1Mllo page
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe transgene contains the human beta actin promoter upstream of a chimeric gene encoding an enhanced tetracycline regulated repressor protein (tTS) that comprises the C-terminal portion of the E. coli Tn10 tetracycline repressor (TetR) protein, the 6-amino acid SV40 large T-antigen nuclear localization signal and the N-terminal 121 amino acids of the human ZNF10 (KOX1) zinc finger protein, which contains the KRAB repressor domain, followed by an SV40 polyadenylation signal. The expression construct is flanked by chicken beta-globin insulators. (J:82970)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
References
Original:  J:82970 Mallo M, et al., Reversible gene inactivation in the mouse. Genomics. 2003 Apr;81(4):356-60
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory