Tg(ACTB-tTS)1Mllo
Transgene Detail

Summary

• Symbol: Tg(ACTB-tTS)1Mllo
• Name: transgene insertion 1, Moises Mallo
• MGI ID: MGI:3717162
• Synonyms: beta-actin-tTS, beta-act-tTS
• Transgene: Tg(ACTB-tTS)1Mllo Location: unknown
• Alliance: Tg(ACTB-tTS)1Mllo page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene contains the human beta actin promoter upstream of a chimeric gene encoding an enhanced tetracycline regulated repressor protein (tTS) that comprises the C-terminal portion of the E. coli Tn10 tetracycline repressor (TetR) protein, the 6-amino acid SV40 large T-antigen nuclear localization signal and the N-terminal 121 amino acids of the human ZNF10 (KOX1) zinc finger protein, which contains the KRAB repressor domain, followed by an SV40 polyadenylation signal. The expression construct is flanked by chicken beta-globin insulators. (J:82970)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:82970 Mallo M, et al., Reversible gene inactivation in the mouse. Genomics. 2003 Apr;81(4):356-60
• All: 11 reference(s)