Syt2^m1Ingm
Chemically induced Allele Detail

Summary

• Symbol: Syt2^m1Ingm
• Name: synaptotagmin II; mutation 1, Ingenium Pharmaceuticals
• MGI ID: MGI:3716868
• Synonyms: synaptotagmin 2^I377N
• Gene: Syt2 Location: Chr1:134574272-134680887 bp, + strand Genetic Position: Chr1, 58.24 cM
• Alliance: Syt2^m1Ingm page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Chemically induced (other)
• Mutation: Nucleotide substitutions
• Mutation details: A point mutation in exon 8 caused a non conservative I377N amino acid substitution in the seventh beta strand of the C2B domain of the protein. (J:108786)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Syt2 Mutation: 38 strains or lines available

Notes

Homozygous mutant mice are severely ataxic.

References

• Original: J:108786 Pang ZP, et al., Genetic analysis of synaptotagmin 2 in spontaneous and Ca(2+)-triggered neurotransmitter release. EMBO J. 2006 May 17;25(10):2039-50
• All: 2 reference(s)