Lynx1^tm1Htz
Targeted Allele Detail

Summary

• Symbol: Lynx1^tm1Htz
• Name: Ly6/neurotoxin 1; targeted mutation 1, Nathaniel Heintz
• MGI ID: MGI:3716630
• Synonyms: Lynx1^-
• Gene: Lynx1 Location: Chr15:74619705-74624828 bp, - strand Genetic Position: Chr15, 34.27 cM
• Alliance: Lynx1^tm1Htz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122965
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding sequence was replaced with a neomycin resistance cassette. Western blot confirmed absence of protein in mutants. (J:122965)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lynx1 Mutation: 11 strains or lines available

References

• Original: J:122965 Miwa JM, et al., The prototoxin lynx1 acts on nicotinic acetylcholine receptors to balance neuronal activity and survival in vivo. Neuron. 2006 Sep 7;51(5):587-600
• All: 9 reference(s)