Card9^tm1Tks
Targeted Allele Detail

Summary

• Symbol: Card9^tm1Tks
• Name: caspase recruitment domain family, member 9; targeted mutation 1, Takashi Saito
• MGI ID: MGI:3715521
• Synonyms: Card9^-
• Gene: Card9 Location: Chr2:26242188-26250930 bp, - strand Genetic Position: Chr2, 18.87 cM
• Alliance: Card9^tm1Tks page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122394
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, including the ATG start codon and the CARD-encoding region, was replaced with a neomycin resistance cassette. Absence of protein was confirmed by immunoblot analysis. (J:122394)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Card9 Mutation: 29 strains or lines available

References

• Original: J:122394 Hara H, et al., The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors. Nat Immunol. 2007 Jun;8(6):619-29
• All: 22 reference(s)