Gab2^tm1Gsf
Targeted Allele Detail

Summary

• Symbol: Gab2^tm1Gsf
• Name: growth factor receptor bound protein 2-associated protein 2; targeted mutation 1, Gen-Sheng Feng
• MGI ID: MGI:3714456
• Synonyms: Gab2^-
• Gene: Gab2 Location: Chr7:96730958-96958158 bp, + strand Genetic Position: Chr7, 53.39 cM, cytoband E2
• Alliance: Gab2^tm1Gsf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122429
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4, encoding amino acids 208-400, was replaced by a targeting vector containing three loxP sites, a TK-NEO cassette and the diphtheria toxin gene. Additionally, a frameshift mutation was introduced. The TK-NEO was removed via Cre-mediated recombination. (J:125541)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gab2 Mutation: 38 strains or lines available

References

• Original: J:122429 Teal HE, et al., GRB2-mediated recruitment of GAB2, but not GAB1, to SF-STK supports the expansion of Friend virus-infected erythroid progenitor cells. Oncogene. 2006 Apr 20;25(17):2433-43
• All: 11 reference(s)