Tg(PSEN1*L235P)1Tang
Transgene Detail

Summary

• Symbol: Tg(PSEN1*L235P)1Tang
• Name: transgene insertion 1, F Tang
• MGI ID: MGI:3714396
• Transgene: Tg(PSEN1*L235P)1Tang Location: unknown
• Alliance: Tg(PSEN1*L235P)1Tang page

Transgene origin

• Strain of Origin: (C57BL/6 x A2G)F1 x BALB/c

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(PSEN1*L235P)1Tang expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PSEN1 (5663)

  Psen1

  (MGI:1202717)

  Transgene codes for a protein with a leucine to proline mutation.

• Mutation details: A mutation was introduced into exon 8 of a human construct. This results in a leucine to proline substitution at amino acid residue 235. (J:122432)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:122432 Huang XG, et al., Behavioral and neurochemical characterization of transgenic mice carrying the human presenilin-1 gene with or without the leucine-to-proline mutation at codon 235. Exp Neurol. 2003 Oct;183(2):673-81
• All: 2 reference(s)