Stx16^tm1Hju
Targeted Allele Detail

Summary

• Symbol: Stx16^tm1Hju
• Name: syntaxin 16; targeted mutation 1, Harald Juppner
• MGI ID: MGI:3714383
• Synonyms: Stx16^delta4-6
• Gene: Stx16 Location: Chr2:173918101-173941564 bp, + strand Genetic Position: Chr2, 97.85 cM
• Alliance: Stx16^tm1Hju page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122325
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The vector contained a self-splicing floxed ACN cassette containing a neo and a cre recombinase gene and was inserted to replace exons 4-6. The final allele contains a sinlge loxP site in place of the exons as the neo and cre were deleted upon passage through the male germline. RT-PCR confirmed successful recombination of the locus in mutant kidney samples. (J:122325)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stx16 Mutation: 21 strains or lines available

References

• Original: J:122325 Frohlich LF, et al., Lack of Gnas epigenetic changes and pseudohypoparathyroidism type Ib in mice with targeted disruption of syntaxin-16. Endocrinology. 2007 Jun;148(6):2925-35
• All: 1 reference(s)