Dyrk4^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Dyrk4^tm1Dgen
• Name: dual-specificity tyrosine phosphorylation regulated kinase 4; targeted mutation 1, Deltagen
• MGI ID: MGI:3713116
• Synonyms: Dyrk^-
• Gene: Dyrk4 Location: Chr6:126852983-126898802 bp, - strand Genetic Position: Chr6, 61.92 cM
• Alliance: Dyrk4^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119704
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 6 and 7, containing parts of the ATP binding domain, were replaced by a neo-lacZ cassette. Northern blot and RT-PCR confirmed absence of transcript in mutants. (J:119704)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dyrk4 Mutation: 29 strains or lines available

References

• Original: J:119704 Sacher F, et al., The expression of the testis-specific Dyrk4 kinase is highly restricted to step 8 spermatids but is not required for male fertility in mice. Mol Cell Endocrinol. 2007 Mar 15;267(1-2):80-8
• All: 1 reference(s)