Tg(GFAP-cre/PGR*)2Kdmc
Transgene Detail

Summary

• Symbol: Tg(GFAP-cre/PGR*)2Kdmc
• Name: transgene insertion 2, Ken D McCarthy
• MGI ID: MGI:3712448
• Synonyms: CrePR2, hGFAP-CrePR2, Tg(GFAP-cre)2Kdmc, Tg(GFAP-cre/PGR)2Kdmc
• Transgene: Tg(GFAP-cre/PGR*)2Kdmc Location: unknown
• Alliance: Tg(GFAP-cre/PGR*)2Kdmc page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: mifepristone
• Mutation: Insertion
• Tg(GFAP-cre/PGR*)2Kdmc expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  GFAP (2670)

  Gfap	(MGI:95697)

• Mutation details: Cre recombinase cDNA with the progesterone receptor was placed under the control of the human glial fibrillary acidic protein promoter. None of the 4 lines that expressed cre/PGR mRNA exhibited inducible recombinase activity after RU486 induction in crosses with reporter mice, so the lines were discontinued. (J:121777)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	GFAP (human) Summary of all recombinase alleles driven by GFAP. Alliance human GFAP gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:121777 Casper KB, et al., Characterization of astrocyte-specific conditional knockouts. Genesis. 2007 May;45(5):292-9
• All: 1 reference(s)