Fen1^tm1Bhsh
Targeted Allele Detail

Summary

• Symbol: Fen1^tm1Bhsh
• Name: flap structure specific endonuclease 1; targeted mutation 1, Binghui Shen
• MGI ID: MGI:3711354
• Synonyms: FFAA
• Gene: Fen1 Location: Chr19:10176496-10181533 bp, - strand Genetic Position: Chr19, 6.54 cM
• Alliance: Fen1^tm1Bhsh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121378
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/Sv

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Nucleotide substitutions
• Mutation details: A targeting vector was designed to insert the FF343-344AA mutation. Transient cre expression removed a floxed neo included in the vector. (J:121378)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fen1 Mutation: 30 strains or lines available

References

• Original: J:121378 Zheng L, et al., Disruption of the FEN-1/PCNA interaction results in DNA replication defects, pulmonary hypoplasia, pancytopenia, and newborn lethality in mice. Mol Cell Biol. 2007 Apr;27(8):3176-86
• All: 4 reference(s)